Recent advances in next generation sequencing have improved our understanding of the important role of gut microbiota in influencing brain development and function; i.e: 'gut-microbiota-brain' (GMB) axis. This is a bi-directional pathway where brain and gut microbes share detailed communications through immunological pathways, hormones and metabolites. GMB plays a crucial role in early brain development and function and impacts on long-term neurodevelopment and neurobehaviour. Understanding these roles is important to understand effective management and potentially prevention. This presentation will cover important aspects of GMB development, physiology, function and translation in clinical medicine for neonates and infants.
Learning Objectives:
1. Describe the physiology, immunology and endocrine elements of gut-microbiota-brain axis.
2. Explain the factors influencing the GMB axis and dysbiosis related illness in neonates and infants.
3. Describe the up to date translational research in GMB axis in neonates and infants and impact on long-term health.
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