Dr. Denney is an Associate Professor of Maternal-Fetal Medicine at Wake Forest School of Medicine in Winston-Salem, NC. He joined the faculty in 2013 after his MFM fellowship at The University of Wisconsin--Madison. Dr. Denney has a joy of teaching and has given a number of lectures locally, regionally, and nationally. He has a keen interest in improving maternal and fetal outcomes and serves as OB Physician Champion of the Northwest Region for the North Carolina Community Care Network. His research interests include hypertensive disorders of pregnancy/preeclampsia, indicated preterm birth, obesity in pregnancy, and immune modulation of pregnancy. Dr. Denney's research efforts have led to over 20 publications and over 40 presentations at regional and national meetings.
Background: Simply stated, preeclampsia is new-onset hypertension with proteinuria during gestation. However, preeclampsia is complex, virtually affects every organ and is often confused with other entities--imitators of preeclampsia.
Methods: My aim is to provide clinicians with a working framework. Such framework is key in identifying underlying disease processes that mimic or predispose patients toward developing hypertensive disorders and evolving manifestations (eg, renal failure in SLE).
Results: Select data will be reviewed to tie in insights with numerous portals and pathophysiologic processes that lead to pre-eclampsia, hypertensive disorders or pregnancy and the so-called imitators of preeclampsia (eg, AFLP, HELLP, SLE, TTP-HUS). Underlying processes or preexisting chronic diseases all lead to an assortment of physiologic dysfunctions affecting uterus and kidney with or without additional organ involvement.
Conclusion: Many disease processes predispose toward preeclampsia and/or imitators of preeclampsia. Regardless of background and ultimate pathway, over-arching principles are shared.
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