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United States

Sarosh Rana, MD

  • Speaker Type: GOLD Obstetrics 2019
  • Country: United States

Dr. Rana cares for women with high-risk pregnancies and is an expert in the diagnosis and management of preeclampsia — a condition characterized by high blood pressure during pregnancy. Dr. Rana aims to improve maternal and fetal outcomes through use of systematic evidence based management protocols and research on preeclampsia. Her research over the last several years has focused on demonstrating clinical utility for angiogenic biomarkers in prediction of adverse outcomes among women with preeclampsia. Dr. Rana performs collaborative research evaluating the relationships between increased levels of angiogenic factors and immediate, as well as future, cardiovascular dysfunction. A dedicated teacher, Dr. Rana trains residents and fellows on the use of ultrasound imaging, as well as the management of women with complex pregnancies.

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Angiogenic Factors and Preeclampsia
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and preeclampsia—are uniquely challenging as the pathology and its therapeutic management simultaneously affect mother and fetus, sometimes putting their well-being at odds with each other. Preeclampsia, in particular, is one of the most feared complications of pregnancy. Often presenting as new-onset hypertension and proteinuria during the third trimester, preeclampsia can progress rapidly to serious complications, including death of both mother and fetus. While the cause of preeclampsia is still debated, clinical and pathological studies suggest that the placenta is central to the pathogenesis of this syndrome. In this talk, we will discuss the current evidence for the role of abnormal placentation and the role of placental factors such as the antiangiogenic factor, sFLT1 (soluble fms-like tyrosine kinase 1) in the pathogenesis of the maternal syndrome of preeclampsia. We will discuss angiogenic biomarker assays for disease-risk stratification and for the development of therapeutic strategies targeting the angiogenic pathway.
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