Milk and Gut Microbes: Early feeding and outcomes in preterm and term neonates

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$15.00 USD
Total CE Hours: 1.00   Access Time: 2 Weeks  
Lectures in this bundle (1):
Durations: 60 mins
Nicholas D. Embleton, MD, MBBS, FRCPCH, BSc
Milk and gut microbes: early feeding and outcomes in preterm and term neonates
UK Nicholas D. Embleton, MD, MBBS, FRCPCH, BSc

Dr Embleton has worked in neonatal medicine for the past 25 years, completing clinical training and a research doctorate in neonatal nutrition in the UK, and a neonatal fellowship in Vancouver, Canada. He has worked as a Consultant Neonatal Pediatrician in Newcastle, UK since 2002, one of the largest UK neonatal units, caring for sick preterm and term born neonates. He leads a broad portfolio of research focused on nutrition and gut health in preterm infants. Areas of work include determining patterns of early gut microbial colonization, and how these may predict the development of necrotizing enterocolitis (NEC) and sepsis. He is a project team member of large neonatal feeding trials recruiting >5000 infants in the UK, as well as coordinating mechanistic studies using microbiomic and metabolomic analyses. He chairs the multi-disciplinary UK Neonatal Nutrition Network (N3) and is a member of the Committee of Nutrition for ESPGHAN.

Objective 1: To understand how bacteria colonise the gut in newborn infants
Objective 2: To understand the relationship between gut microbes, nutrients and health and disease outcomes in infancy
Objective 3: To appreciate how feeding method, milk type, probiotics and antibiotics ‘shape’ the gut microbiota

UK Nicholas D. Embleton, MD, MBBS, FRCPCH, BSc
Abstract:

There is increasing evidence that the pattern of gut microbes affects a range of health and disease outcomes for both term and preterm infants. At birth, the gastro-intestinal tract is largely sterile, but rapidly becomes colonized by organisms in the environment, contact with the mother and from breast milk. The numerous advantages of breast milk throughout the life-course may be due, in part, to the patterns of early gut bacteria, and the interactions between milk, microbes and the immune system. These interactions are likely to be pivotal to the development of infections and necrotising enterocolitis (NEC, a serious inflammatory gut complication) in preterm infants. Data show that early colonisation in preterm infants on NICUs is profoundly abnormal. However, knowing how these patterns are affected by milk type, immuno-nutrients (such as lactoferrin), antibiotics and probiotics is important as it may allow the design of strategies to improve health outcomes.

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There is increasing evidence that the pattern of gut microbes affects a range of health and disease outcomes for both term and preterm infants. At birth, the gastro-intestinal tract is largely sterile, but rapidly becomes colonized by organisms in the environment, contact with the mother and from breast milk. The numerous advantages of breast milk throughout the life-course may be due, in part, to the patterns of early gut bacteria, and the interactions between milk, microbes and the immune system. These interactions are likely to be pivotal to the development of infections and necrotising enterocolitis (NEC, a serious inflammatory gut complication) in preterm infants. Data show that early colonisation in preterm infants on NICUs is profoundly abnormal. However, knowing how these patterns are affected by milk type, immuno-nutrients (such as lactoferrin), antibiotics and probiotics is important as it may allow the design of strategies to improve health outcomes.

Tags / Categories

Breastfeeding and Lactation

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